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KMID : 0605720020080010164
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Journal of the Korean Society of Biological Therapies in Psychiatry
2002 Volume.8 No. 1 p.164 ~ p.175
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Differences between Early Onset Depression and Late Onset Depression among Elderly : Clinical and Biological Perspectives
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김문두/Moon Doo Kim
박용진/Yong Jin Park
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Abstract
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Objects: The purpose of this study was to review the clinical and biological differences between early onset depression and late onset depression among elderly.
Methods: The author reviewed the medical literature covering the past 25 years.
Results: There is strong relationship between late-onset depression and brain abnormality, including subcortical, deep white matter hyperintensity. Late-onset depression also has strong relation with vascular disorder and dementia.
Early-onset
depression has strong genetic component, while late-onset depression has more environmental component rather than genetric component. Medical burden, life events and stress influence elderly through bidirectional way.
Conclusions: Late-onset depression is heterogeneous disorder. It appears that both type of geriatric depression has different etiology, similar phenomenology. Further investigation will be needed to develop ways to identify geriatric
depression
in community early in disease course and enhance therapeutic efficacy and speed therapeutic responses to avoid serious complication such as suicice and high mortality.
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KEYWORD
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